In today's rapidly evolving health care landscape, the trustworthiness of medical evidence remains a fundamental pillar, essential not only to the biopharmaceutical industry but also to the regulatory bodies that govern it. As the generation of medical evidence expands, companies must refine their methods and adopt advanced tools to keep pace. By embracing a more comprehensive approach to evidence generation, they can provide health care providers, patients, regulators, and policymakers with the critical data they need, ultimately improving patient outcomes and strengthening the foundation of health care systems.